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Follow-On Cancer Drugs Target Earlier Stages Than Initial Drugs: Implications Of The IRA

In an ahead-of-print article published this week, Tomas J. Philipson and coauthors explore how mandates from the Inflation Reduction Act (IRA) resulted in shortening the exclusivity period used to recoup research and development investments as well as support follow-on innovation.

The study shows that oncology follow-on approvals frequently shift to earlier disease stages, a trend that may be accelerated by IRA-induced incentives.

This article will be featured in our December 2025 issue. Subscribe to the journal to never miss out on an upcoming issue.

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A Health Podyssey: Does UnitedHealthcare Pay Optum Providers Differently? w/ Dan Arnold

Health Affairs This Week: Keeping ACO Models Accountable

Ask the Health Affairs Editors

Join Health Affairs on December 3 for an exclusive Insider virtual event to hear our editors discuss 2025's most memorable submissions and take audience questions.

Editors to join the event include:

Don Metz, Executive Editor and Interim Editor-in-Chief
Jessica Bylander, Deputy Editor
Kathleen Haddad, Senior Editor
Ellen Bayer, Senior Editor
Marianne Amoss, Senior Editor

Save Your Spot

Medicare ACOs In 2024: Increased Participation And Evolving Policy Impacts

Audrey Ford et al.

part of our Accountable Care For Population Health series

The 340B Rebate Pilot Model: Weighing 340B Program Integrity Against Financial Stability For The Safety Net

Sayeh Nikpay

Challenging The Administration’s Weaponized And Lethal “Gold Standard Science”

Nancy Krieger

part of our Health Policy At A Crossroads series

The No UPCODE Act: Considering A Simple Start To A Complex Problem

J. Michael McWilliams

When ACIP Abandons Clarity, Public Health Suffers

Ram Koppaka

part of our Health Policy At A Crossroads series

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