From Immunize.org <[email protected]>
Subject IZ Express #1,824: No harm from aluminum in vaccines, back-to-school vaccine campaign, and more
Date July 23, 2025 10:02 AM
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Issue 1,824: July 23, 2025
Top Stories
* Study finds no relationship between aluminum in vaccines and a wide variety of chronic childhood health problems (#IZX1)
* Vaccinate Your Family launches back-to-school vaccination awareness campaign; spread the word using its FirstDayVax toolkit in English and Spanish (#IZX2)
* FDA licenses prefilled syringe option for Shingrix (GSK) to prevent shingles (#IZX3)
* Measles spreads further, with 1,309 cases across 39 states (#IZX4)
* Alternative vaccination schedules: watch the 2-minute explanation, part of the Ask the Experts Video Series on YouTube (#IZX5)
* Vaccines in the news (#IZX6)


Immunize​.org Website and Clinical Resources
* Spotlight on the website: Web page footer links lead to Immunize​.org information (#IZX7)


Featured Resources
* ACOG shares new Maternal Immunization Social Media Toolkit with messaging and training for patients and clinicians (#IZX8)
* Use Immunize​.org's "Key Vaccination Resources for Healthcare Professionals" to train new and seasoned staff (#IZX9)
* Teaching children and teens about vaccination: reliable resources on how vaccines work (#IZX10)
* Immunize​.org's elegantly designed "Vaccines Save Lives" black enamel pins remind patients and families why we work so hard to prevent disease (#IZX11)

Notable Publications
* “Vaccination as a New Form of Cardiovascular Prevention: a European Society of Cardiology Clinical Consensus Statement . . .” published in European Heart Journal (#IZX12)
* “Disparities in Rural and Urban Outcomes in Populations with Human Papillomavirus–Associated Oropharyngeal Cancers” published in Journal of Rural Health (#IZX13)


Global News
* WHO and UNICEF issue joint press release on global immunization coverage for 2024, highlighting troubling trajectory in progress toward global immunization target for 2030 (#IZX14)


Upcoming Events
* Virtual: Register for Immunize​.org Website Office Hours. Ask questions and learn about the “Official Guidance” (state resources) web section on Immunize​.org on August 6 at 4:00 p.m. (ET) or August 7 at 12:00 p.m. (ET). Recorded sessions archived. (#IZX15)


Editorial Information (#Editorial)
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Top Stories
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Study finds no relationship between aluminum in vaccines and a wide variety of chronic childhood health problems

In its July 15 issue, Annals of Internal Medicine published Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood ([link removed]) . This large study in Denmark found no evidence of a relationship between the use of aluminum-containing vaccines and 50 different disorders affecting children. The results of this study are timely and reassuring, given renewed media attention and questions raised about the safety of aluminum in vaccines. A portion of the results section appears below.

Cumulative aluminum exposure from vaccination during the first 2 years of life was not associated with increased rates of any of the 50 disorders assessed. For groups of combined outcomes, adjusted hazard ratios per 1-mg increase in aluminum exposure were [unchanged] . . . for any autoimmune disorder, . . . any atopic or allergic disorder, and . . . any neurodevelopmental disorder. For most individually analyzed outcomes, the upper bounds of the 95% CIs were incompatible with relative increases greater than 10% or 30%.

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Related Link
* Medscape: Aluminum in Vaccines Not Linked to Chronic Childhood Disorders: Danish Study ([link removed]) (7/14/25)

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Vaccinate Your Family launches back-to-school vaccination awareness campaign; spread the word using its FirstDayVax toolkit in English and Spanish

Vaccinate Your Family ([link removed]) (VYF) launched its #FirstDayVax campaign ([link removed]) to remind families that vaccines should be part of every back-to-school checklist. This campaign celebrates the protection vaccines provide and empowers parents with information to make timely, informed choices. Find the shareable assets in the #FirstDayVax toolkit ([link removed]) , also available in Spanish ([link removed]) .

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To extend the campaign's reach, use the #FirstDayVax hashtag on social media and tag @vaccinateyourfamily (@vaxyourfam on X).
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FDA licenses prefilled syringe option for Shingrix (GSK) to prevent shingles

On July 17, FDA licensed ([link removed]) the prefilled syringe option for Shingrix (GSK) for the prevention of shingles. Prefilled syringes are simpler to use than the 2-vial Shingrix package that requires a reconstitution step.

ACIP and CDC recommend vaccination of the following people to prevent shingles and post-herpetic neuralgia, the chronic pain that may linger long after the acute shingles rash resolves:
* All adults age 50 years and older who have not received Shingrix
* Adults age 19 years and older with a weakened immune system because of disease or treatments

Related Links
* FDA: Shingrix ([link removed]) web page
* FDA: Shingrix package insert ([link removed]) (PDF)
* Immunize​.org: Package Inserts and FDA Product Approvals ([link removed]) main page

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Measles spreads further, with 1,309 cases across 39 states

As of July 16, CDC reported 1,309 confirmed measles cases ([link removed]) in 2025 in 39 states, including the first cases reported this year in South Carolina. Among confirmed cases of all ages, 13% were hospitalized. Among those younger than age 5 years, 21% were hospitalized.

CDC only requires reporting of laboratory-confirmed measles cases. Cases without laboratory testing for confirmation are not included in these numbers. Actual numbers of cases are, therefore, higher than confirmed case counts.

A map of 2025 measles cases ([link removed]) in the contiguous United States, as of July 17, from the Johns Hopkins International Vaccine Access Center ([link removed]) , appears below. The U.S. Measles Tracker ([link removed]) website includes state and county-level data.

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Immunize​.org offers measles-related resources for the public on several of our affiliated websites:
* VaccineInformation​.org: Measles ([link removed]) web page
* LetsGetRealAboutVaccines​.org: Measles ([link removed]) web page
* Immunize​.org: Vaccines A–Z: Measles ([link removed]) main page

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Other credible sources include:
* HistoryofVaccines​.org: Measles ([link removed]) web page
* Vaxopedia: Measles Protection Questions and Answers ([link removed]) web page

Related Links
* CDC: Measles Cases and Outbreaks ([link removed]) main page
* CDC: Be Ready for Measles Toolkit ([link removed])
* Center for Outbreak Response Innovation: Measles Outbreak Response ([link removed]) main page
* Immunize​.org: Vaccines A–Z: Measles ([link removed]) main page
* Immunize​.org: Ask the Experts: MMR (Measles, Mumps, and Rubella) ([link removed]) web page

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Alternative vaccination schedules: watch the 2-minute explanation, part of the Ask the Experts Video Series on YouTube

This week, our featured episode from the Ask the Experts Video Series is titled Alternative Schedules ([link removed]) . The video describes how there is no scientific evidence of any benefit to delaying or separating vaccinations beyond the published recommended schedule of childhood vaccinations. In fact, delaying vaccination unnecessarily prolongs a child’s risk of infection.

The 2-minute video is available on our YouTube channel ([link removed]) , along with our full collection of quick video answers to popular Ask the Experts ([link removed]) questions.

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Like, follow, and share Immunize​.org’s social media accounts and encourage colleagues and others interested in vaccination to do likewise.
* Facebook at ImmunizeOrg ([link removed])
* Instagram at ImmunizeOrg ([link removed])
* LinkedIn at ImmunizeOrg ([link removed])
* YouTube at ImmunizeOrg ([link removed])

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Vaccines in the news

These recent articles convey the potential risks of vaccine-preventable diseases and the importance of vaccination.
* New York Times: Kennedy Claims Doctors Profit Off Vaccines. In Fact, Many Lose Money on Them. ([link removed]) (7/15/25)
* Medscape: How to Talk Vaccines with Skeptics: 5 Tips from a Doctor ([link removed]) (7/15/25)
* Medpage Today: Can a Novel Motivational Interviewing Technique Help in the Measles Outbreak? ([link removed]) (7/14/25)

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Immunize​.org Website and Clinical Resources
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Spotlight on the website: Web page footer links lead to Immunize​.org information

This week’s Spotlight focuses on the content found at the bottom of each web page of Immunize​.org.

“Our Affiliated Sites” section provides links to six websites that are part of and maintained by our 501(c)3 nonprofit organization. Each reflects various aspects of our mission.
* VaccineInformation​.org: providing resources to the public about vaccines and vaccine-preventable diseases
* ImmunizationCoalitions​.org: providing information to coalitions about and for the National Network of Immunization Coalitions
* LetsGetRealAboutVaccines​.org: answering parents’ and providers’ questions about pediatric vaccines and diseases
* Influenza-defense​.org: the 65+FluDefense site sharing the essentials of protecting older adults from seasonal influenza
* Give2MenAcwy​.org: sharing resources to support vaccination with two doses of MenACWY vaccine to fully protect adolescent patients
* Izsummitpartners​.org: the National Adult and Influenza Immunization Summit (NAIIS) site provides information and resources for the many partner organizations that address influenza and adult vaccination issues

The dark-blue box below the affiliated sites links to:
* Our social media pages
+ Facebook
+ Instagram
+ LinkedIn
+ YouTube
* Information about Immunize​.org, including "Our Mission" and "Our People"
* Ways to support our work: “Shop” and “Donate”
* How to contact us, including an online form and telephone
* Subscription information for IZ Express

To learn more, watch these related videos: 
* Video: Introducing Immunize.org ([link removed]) (3 minutes)
* Video: Introducing News and Updates Menu ([link removed]) (3 minutes)
* Video: Website Office Hours: Affiliated Websites ([link removed]) (44 minutes)

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Featured Resources
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ACOG shares new Maternal Immunization Social Media Toolkit with messaging and training for patients and clinicians

The American College of Obstetricians and Gynecologists ([link removed]) (ACOG) released its Maternal Immunization Social Media Toolkit ([link removed]) , designed to provide healthcare professionals with ready-to-use social media messaging to promote the COVID-19, influenza, RSV, and Tdap vaccines during pregnancy. Messages available are specific for either patient or clinician audiences.

The toolkit features sample posts, resources, and graphics to keep patients informed and to encourage your networks to promote maternal immunization. While the messages, resources, and graphics are endorsed by ACOG, language can be adapted to suit your own voice.

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Please share the Maternal Immunization Social Media Toolkit ([link removed]) with partners who can spread these messages further.
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Use Immunize​.org's "Key Vaccination Resources for Healthcare Professionals" to train new and seasoned staff

Immunize​.org offers an annotated list of key training, education, and reference materials for people who vaccinate or oversee vaccination clinics. Key Vaccination Resources for Healthcare Professionals ([link removed]) provides vaccinators with a strong foundation for building and sustaining vaccination skills.

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Related Links
* Immunize​.org: Skills Checklist for Vaccine Administration ([link removed] ) (PDF)
* Immunize​.org: Clinical Resources: Administering Vaccines ([link removed]) main page
* Immunize​.org: Clinical Resources A–Z ([link removed]) main page, where you can filter by topic, vaccine, language, or other criteria

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Teaching children and teens about vaccination: reliable resources on how vaccines work

Planning for the upcoming school year or looking for science projects? The resources below can help children and adolescents explore vaccines and the immune system.

For elementary school children
* The Vaccine Makers Project: Elementary School Lesson Plans ([link removed]) (3/7/18)
* CHOP: Vaccine Resources for Kids and Teens ([link removed]) includes:
+ My Vaccine Activity Book ([link removed]) (view in Spanish ([link removed]) )
+ Vax Pack Hero ([link removed]) video game
+ Various storybooks and comic books ([link removed])
* Peekaboo Kidz, The Dr Binocs Show: How Vaccines Work ([link removed]) (6:50 min.; 4/24/20)
* SciShow Kids: Why Do We Get Vaccines? ([link removed]) (3:30 min.; 11/14/17)
* TED-Ed: How Do Vaccines Work? ([link removed]) (4:35 min.; 1/12/15)

For middle school children
* The Vaccine Makers Project: Middle School Lesson Plans ([link removed])
* CDC: How Does Flu Make You Sick? ([link removed]) (57 sec.; 11/4/19)
* Science Journal for Kids and Teens: 6 Scientific Articles about Vaccination ([link removed]) for middle and high school students
* Voices for Vaccines: Thomas Jefferson to Edward Jenner ([link removed]) (1:49 min.; 7/3/18)
* UNICEF: Vaccine Education, for and with Youth ([link removed]) (4/29/24)

For high school students
* History of Vaccines: Historyofvaccines.org ([link removed])
* The Vaccine Makers Project: High School Lesson Plans ([link removed])
* Kurzgesagt—In a Nutshell: The Side Effects of Vaccines—How High Is the Risk? ([link removed]) (10:55 min.; 5/12/19)
* Science News Explores: Explainer: What Is a Vaccine? ([link removed]) (7/18/17)
* Vaxopedia ([link removed]) website
* Science Journal for Kids and Teens: 6 Scientific Articles about Vaccination ([link removed]) for middle and high school students

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Immunize​.org's elegantly designed "Vaccines Save Lives" black enamel pins remind patients and families why we work so hard to prevent disease

Immunize​.org’s elegantly designed “Vaccines Save Lives” pins ([link removed]) are meaningful gifts for people who care about vaccination. The pin makes a refined statement in hard black enamel with gold lettering and edges, measuring 1.125" x 0.75". The pin features a stick-through-post with the back covered by a round rubber cap that holds the pin securely. A gold metal spring-lock clasp is also provided.

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Wear these pins on clothing, ([link removed]) uniforms, and white coats to show that you value vaccines.

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Click here for "Vaccines Save Lives" pin pricing and ordering information. ([link removed])
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Notable Publications
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“Vaccination as a New Form of Cardiovascular Prevention: a European Society of Cardiology Clinical Consensus Statement . . .” published in European Heart Journal

In its June 30 issue, European Heart Journal published Vaccination as a New Form of Cardiovascular Prevention: a European Society of Cardiology [ESC] Clinical Consensus Statement: With the contribution of the European Association of Preventive Cardiology (EAPC), the Association for Acute CardioVascular Care (ACVC), and the Heart Failure Association (HFA) of the ESC ([link removed]) . Although issued by European cardiology societies, the evidence and cardiac benefits described are relevant to the American population. Heart disease is the leading cause of death in the United States. The importance of vaccination to cardiovascular health is underappreciated by healthcare professionals and the public. The abstract is printed below.

Vaccination is increasingly acknowledged as an effective preventive measure not only against specific infections, but also for the prevention of cardiovascular disease in high-risk patients. Specifically, a growing body of evidence suggests that vaccines against influenza, SARS-CoV-2, respiratory syncytial virus, herpes zoster, and other viruses significantly reduce infection and for influenza the incidence of major adverse cardiovascular events in vaccinated individuals.

This clinical consensus statement examines the existing literature and accumulated evidence and offers practical clinical advice on vaccination timing and target demographics, specifically addressing complex clinical scenarios with a focus on cardiovascular conditions. It includes guidelines for vaccinating vulnerable populations such as immunosuppressed individuals, patients with congenital heart disease, and pregnant women as well as safety and potential complications of the procedure.

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Geographical Abstract Pathogens with increased cardiovascular (CV) risk: vaccine prevention against pathogens such as influenza and pneumococcus can reduce the risk for major adverse cardiovascular events (MACE). The benefit is particularly strong in susceptible risk groups such as older individuals, patients with congenital heart disease, heart transplant or coronary artery disease, as well as in pregnant women. SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, RSV, respiratory syncytial virus.
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“Disparities in Rural and Urban Outcomes in Populations with Human Papillomavirus–Associated Oropharyngeal Cancers” published in Journal of Rural Health

In its July 10 issue, Journal of Rural Health published Disparities in Rural and Urban Outcomes in Populations with Human Papillomavirus–Associated Oropharyngeal Cancers ([link removed]) . This retrospective study used the Surveillance, Epidemiology, and End Results (SEER) Pharyngeal Cancer with HPV Status Database from 2006 to 2018. Among people diagnosed with HPV-associated oropharyngeal cancer, the study assessed the difference in overall survival and cause-specific mortality between rural and urban populations.

An excerpt from the abstract appears below.

Results: A total of 13,294 patients were included in our study, most of whom lived in urban counties (88.5%, n = 11,766), had a mean age of 60.6 years . . . and had a primary tumor site located in the tonsil (47.6%, n = 6328). Rural communities had a higher likelihood of all-cause mortality . . . compared to their urban counterparts. Additionally, rural residents had a higher probability of cause-specific mortality . . . compared to their urban counterparts.

Conclusions: Patients with HPV-associated oropharyngeal cancer who reside in rural areas were more likely to die when compared to their urban counterparts. More research is needed to determine the best way to mitigate this disparity.
HPV vaccination is crucial to preventing HPV-associated cancers, but HPV vaccination rates are lower among rural teens than teens in urban areas. One way these disparities in disease outcomes can be addressed over time is by reducing disparities in rural and urban HPV vaccination rates and increasing HPV vaccination overall.

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Global News
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WHO and UNICEF issue joint press release on global immunization coverage for 2024, highlighting troubling trajectory in progress toward global immunization target for 2030

On July 15, WHO and UNICEF issued a joint press release titled Global Childhood Vaccination Coverage Holds Steady, Yet over 14 Million Infants Remain Unvaccinated – WHO, UNICEF ([link removed]) . At the same time, WHO released its summary of immunization coverage ([link removed]) . A portion of the summary appears below.

While immunization is one of the most successful public health interventions, coverage has held steady since 2023, but data highlight a troubling trajectory in progress toward key targets of the global Immunization Agenda 2030 (IA2030).

During 2024, about 85% of infants worldwide (109 million) received 3 doses of diphtheria-tetanus-pertussis (DTP3) vaccine, protecting them against infectious diseases that can cause serious illness and disability or be fatal. However, these global figures hide significant disparity among countries of different income strata, with low-income countries lagging behind.

Measles, because of its high transmissibility, acts as an early warning system, quickly exposing immunity gaps in the population. Still, 20.6 million children missed their routine first dose of measles, far from the 2019 level of 19.3 million.

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Related Links
* WHO: Global Childhood Vaccination Coverage Holds Steady, Yet over 14 Million Infants Remain Unvaccinated – WHO, UNICEF ([link removed]) (7/15/25)
* WHO: Immunization Coverage ([link removed]) (7/15/25)
* WHO: Immunization Agenda 2030 ([link removed]) web page

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Upcoming Events
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Virtual: Register for Immunize​.org Website Office Hours. Ask questions and learn about the “Official Guidance” (state resources) web section on Immunize​.org on August 6 at 4:00 p.m. (ET) or August 7 at 12:00 p.m. (ET). Recorded sessions archived.

To learn simple tips and tricks for using our website efficiently, please register for our next set of Website Office Hours on Wednesday, August 6 at 4:00 p.m. (ET) ([link removed]) or Thursday, August 7 at 12:00 p.m. (ET) ([link removed]) . The same content will be covered in both sessions.

We will open each 45-minute session with a short, live demonstration on navigating the Official Guidance ([link removed]) (state resources) website section on Immunize​.org. This section is useful for those who want to know about state immunization requirements for school and childcare. You can submit questions when you register or live on Zoom during the session.

Register today for Immunize​.org Website Office Hours (content is the same for both):
* Wednesday, August 6 at 4:00 p.m. (ET) ([link removed])
* Thursday, August 7 at 12:00 p.m. (ET) ([link removed])

The archive of previous Website Office Hours content ([link removed]) is posted at Immunize​.org’s "Webinars & Videos" page. These archived programs include Ask the Experts; Clinical Resources; Vaccine Information Statements (VISs); Affiliated Websites; Images, Webinars, Videos, & Social Media; Let's Get Real About Vaccines Website; News & Updates; Official Guidance Part 1 & 2; Publication Archives, Vaccine Timeline, & About Us; Travel Vaccines, Vaccine Confidence, & Addressing Concerns; and Vaccines A–Z.

Mark your calendar ([link removed])  for future Immunize​.org Website Office Hours.

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For more upcoming events, visit our Calendar of Events ([link removed]) .
Editorial Information
Editor-in-Chief
Kelly L. Moore, MD, MPH
Managing Editor
John D. Gr
äbenstein, RPh, PhD
Associate Editor
Sharon G. Humiston, MD, MPH
Writer/Publication Coordinator
Taryn Chapman, MS
Courtnay Londo, MA
Style and Copy Editor
Marian Deegan, JD
Web Edition Managers
Arkady Shakhnovich
Jermaine Royes
Contributing Writer
Laurel H. Wood, MPA
Technical Reviewer
Kayla Ohlde

About IZ Express
Immunize​.org welcomes redistribution of this issue of IZ Express or selected articles.
When you do so, please add a note that Immunize​.org is the source of the material and provide a link to this issue ([link removed]) .

IZ Express is supported in part by Grant No. NH23IP922654 from the National Center for Immunization and Respiratory Diseases, CDC. Its contents are solely the responsibility of Immunize​.org and do not necessarily represent the official views of CDC.

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